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Related terms
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    Related terms
    • Brand Names: U.S.: Compro®
    • Brand Names: Canada: Apo-Prochlorperazine®;Nu-Prochlor;PMS-Prochlorperazine;Sandoz-Prochlorperazine

    • It is used to treat anxiety.
    • It is used to treat upset stomach and throwing up.
    • It is used to treat schizophrenia. It may take 6 weeks to see the full effect.
    • Prochlorperazine helps clear thinking.
    • It works on helping social interactions, mood, expression of mood, as well as, delusions, paranoia, and look.
    • It affects the throwing up (vomiting) center in the brain.


    How to take

    • Take with or without food. Take with food if it causes an upset stomach.
    • Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
    • Use suppository rectally.
    • Shot:
    • It is given as a shot into a muscle or vein.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.
    • Many times this drug is taken on an as needed basis.


    • Store at room temperature.
    • Protect from light.
    • Protect tablets from water. Do not store in a bathroom or kitchen.
    • This drug will be given to you in a hospital or doctor's office. You will not store it at home.



    • There is a higher chance of death in older adults who take this drug for memory problems (dementia).
    • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.


    • Do not give to a child younger than 2 years of age or weighing less than 20 pounds (9 kilograms).
    • If you have an allergy to prochlorperazine or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have Reye's syndrome.


    • If you have an allergy to any type of nuts or seeds, talk with your doctor. Some products have nuts in them.
    • If you have glaucoma, talk with your doctor.
    • If you have heart disease, talk with your doctor.
    • If you have myasthenia gravis, talk with your doctor.
    • If you have Parkinson's disease, talk with your doctor.
    • If you have seizures, talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Avoid beer, wine, mixed drinks, or other drugs and natural products that slow your actions.
    • You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
    • Be careful in hot weather. Drink lots of fluids to stop fluid loss.
    • Tell your doctor if you are pregnant or plan on getting pregnant.
    • Tell your doctor if you are breast-feeding.

    Side Effects

    • Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you.
    • Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing.
    • Nervous and excitable.
    • Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative.
    • Dry mouth. Good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. See a dentist often.
    • Weight gain.
    • Change in sex ability. This most often goes back to normal.


    • Change in the health problem being treated. Is it better, worse, or about the same?
    • Dry mouth may cause more cavities. Take good care of your teeth. See a dentist often.
    • Follow up with the doctor.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Very bad dizziness or passing out.
    • Big change in balance.
    • Shakiness, trouble moving around, or stiffness.
    • Very nervous and excitable.
    • Not able to pass urine.
    • Feeling very tired or weak.
    • For women, if you get pregnant while taking this drug.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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