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    Related terms
    • U.S. Brand Names: Adoxa®;Adoxa® PakT 1/150;Adoxa® PakT 1/75;AlodoxT;Doryx®;Doxy 100T;Monodox®;OcudoxT;Oracea®;OraxylT;Periostat®;Vibramycin®
    • Canadian Brand Names: Apo-Doxy Tabs®;Apo-Doxy®;Dom-Doxycycline;Doxycin;Doxytab;Novo-Doxylin;Nu-Doxycycline;Periostat®;PHL-Doxycycline;PMS-Doxycycline;Vibra-Tabs®;Vibramycin®
    • Mexican Brand Names: Biomixin;Ciclonal;Domiken;Genobiotic-Doxi;Vibramicina;Vivradoxil
    • Pharmacologic Category: Antibiotic, Tetracycline Derivative

    • This medicine is used to treat acne.
    • This medicine is used to prevent or treat a variety of bacterial infections.
    • This medicine is used to treat adult periodontitis. It is used with scaling and root planing.
    • OraceaT: This medicine is used to treat rosacea.
    • Doxycycline works to injure the bacteria and fight the infection.


    How to take

    • To gain the most benefit, do not miss doses.
    • Use prescription as directed, even if feeling better.
    • OraceaT: Take this medicine on an empty stomach. Take 1 hour before or 2 hours after meals.
    • Take this medicine with or without food. Take with food if it causes an upset stomach.
    • A liquid (suspension, syrup) is available if you cannot swallow pills. Shake suspension well before use.
    • Those who have feeding tubes can also use the liquid. Flush the feeding tube before and after medicine is given.
    • Stop tube feeding for 2 hours before giving this medicine. Restart tube feeding 1 hour after giving.
    • Tablets and capsules:
    • Take this medicine (tablets and capsules) with a full glass of water.
    • Doryx®: You may sprinkle tablet contents in applesauce. Carefully break tablet without crushing pellets. Do not chew.
    • Do not lie down for at least 30 minutes after taking this medicine. This prevents irritation to the esophagus (swallowing tube).
    • Injection:
    • This medicine is given as a shot into a vein over a period of time.

    Missed Dose

    • Take a missed dose as soon as possible.
    • If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
    • Do not take a double dose or extra doses.
    • Do not change dose or stop medicine. Talk with healthcare provider.


    • Store at room temperature.
    • Protect from light.
    • Protect capsules and tablets from moisture. Do not store in a bathroom or kitchen.
    • Store liquid (suspension) at room temperature or in a refrigerator. Do not freeze. Throw away any unused portion after 2 weeks.
    • Throw away any unused portion of medicine.
    • Follow directions for storage of injection. Talk with healthcare provider.



    • This medicine does not mix well with some medicines. Serious reactions may occur. Check all medicines with healthcare provider.


    • If you have an allergy to doxycycline or any other part of this medicine.
    • If you have a sulfite allergy, talk with healthcare provider.
    • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.
    • If you have liver disease.
    • If you are pregnant or may be pregnant.


    • Check medicines with healthcare provider. This medicine may not mix well with other medicines.
    • Do not take bismuth (Pepto-Bismol®), calcium, iron, magnesium, zinc, multivitamins with minerals, colestipol, cholestyramine, didanosine, or antacids within 2 hours of this medicine.
    • Avoid alcohol (includes wine, beer, and liquor).
    • You can get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen; wear protective clothing and eyewear.
    • Use birth control that you can trust to prevent pregnancy while taking this medicine.
    • Tell healthcare provider if you are breast-feeding.

    Side Effects

    • Belly pain.
    • Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Diarrhea. Yogurt, Bifidobacterium bifidum, or Lactobacillus acidophilus may help. These products are available at health food stores or in some pharmacies.
    • Not hungry.
    • For females, vaginal yeast infection. Report itching or discharge.
    • Side effects from Periostat® are less.


    • Change in condition being treated. Is it better, worse, or about the same?
    • Follow up with healthcare provider.

    Contact a healthcare provider

    • If you suspect an overdose, call your local poison control center or emergency department immediately.
    • Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
    • Severe headache.
    • Severe nausea or vomiting.
    • Severe diarrhea, even after medicine is stopped.
    • Any rash.
    • No improvement in condition or feeling worse.

    General Statements

    • If you have a life-threatening allergy, wear allergy identification at all times.
    • Do not share your medicine with others and do not take anyone else's medicine.
    • Keep all medicine out of the reach of children and pets.
    • Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada return any unused drugs back to the pharmacy. Also, visit for more facts about the right way to get rid of unused drugs.
    • Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
    • Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
    • Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

    Author information
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    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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