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Articaine Hydrochloride and Epinephrine


Related terms
Author information


    Related terms
    • U.S. Brand Names: Septocaine® with epinephrine 1:100,000;Septocaine® with epinephrine 1:200,000;ZorcaineT
    • Canadian Brand Names: Astracaine® with epinephrine 1:200,000;Astracaine® with epinephrine forte 1:100,000;Septanest® N;Septanest® SP;Ultracaine® DS;Ultracaine® DS Forte;ZorcaineT
    • Pharmacologic Category: Local Anesthetic

    • This medicine is used before dental procedures to numb the area.
    • Articaine numbs the nerves in the area applied.
    • Epinephrine lengthens the effect of articaine.


    How to take

    • Your healthcare provider will give this medicine.
    • This medicine is given as a shot into the skin.


    • This medicine will be given to you in a healthcare setting. You will not store it at home.



    • This medicine does not mix well with some medicines. Serious reactions may occur. Check all medicines with healthcare provider.


    • If you have an allergy to articaine, epinephrine, or any other part of this medicine.
    • If you have a sulfite allergy, talk with healthcare provider.
    • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.


    • Check medicines with healthcare provider. This medicine may not mix well with other medicines.
    • Do not eat while your mouth feels numb. You may injure yourself by biting your tongue.
    • If you have a weakened heart, talk with healthcare provider.
    • Tell healthcare provider if you are pregnant or plan on getting pregnant.
    • Tell healthcare provider if you are breast-feeding.

    Side Effects

    • Irritation where the shot is given.

    Contact a healthcare provider

    • If you suspect an overdose, call your local poison control center or emergency department immediately.
    • Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
    • Significant change in balance.
    • Sudden change in vision, eye pain, or irritation.
    • Weakness, numbness, or tingling.
    • Severe skin irritation.
    • Significant change in thinking clearly and logically.
    • Any rash.
    • No improvement in condition or feeling worse.

    General Statements

    • If you have a life-threatening allergy, wear allergy identification at all times.
    • Do not share your medicine with others and do not take anyone else's medicine.
    • Keep all medicine out of the reach of children and pets.
    • Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada return any unused drugs back to the pharmacy. Also, visit for more facts about the right way to get rid of unused drugs.
    • Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
    • Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
    • Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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