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Oxymetazoline (Nasal)


Related terms
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    Related terms
    • U.S. Brand Names: 12 Hour Nasal Relief [OTC];4-Way® 12 Hour [OTC];Afrin® Extra Moisturizing [OTC];Afrin® Original [OTC];Afrin® Severe Congestion [OTC];Afrin® Sinus [OTC];Dristan® [OTC];Duramist Plus [OTC];Neo-Synephrine® Nighttime12-Hour [OTC];Nostrilla® [OTC];NRS® [OTC];Sudafed OM® Sinus Congestion [OTC] [DSC];Vicks® Early DefenseT [OTC] [DSC];Vicks® Sinex® VapoSpray 12-Hour;Vicks® Sinex® VapoSpray 12-Hour UltraFine Mist [OTC];Vicks® Sinex® VapoSpray Moisturizing 12-Hour UltraFine Mist [OTC]
    • Canadian Brand Names: Claritin® Allergic Decongestant;Dristan® Long Lasting Nasal;Drixoral® Nasal
    • Pharmacologic Category: Adrenergic Agonist Agent;Imidazoline Derivative

    • It is used to treat nose stuffiness.
    • Oxymetazoline shrinks swollen nose tissue and opens up passages.


    How to take

    • Do not take this drug by mouth. For the nose only. Keep out of mouth and eyes (may burn).
    • Blow your nose before use.
    • Do not use for more than 3 days in a row.

    Missed Dose

    • Use a missed dose as soon as you think about it.
    • If it is close to time for the next dose, skip the missed dose and return to your normal time.
    • Do not use two doses or extra doses.
    • Many times this drug is used on an as needed basis.


    • Store at room temperature.



    • Unsafe reactions may happen. This drug cannot be taken while you are taking certain other drugs. Check all the drugs you are taking with your doctor.


    • If you have an allergy to oxymetazoline or any other part of this drug.
    • Tell doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs involved.
    • If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this drug is started. Taking the two at the same time could cause risky high blood pressure.


    • Do not use for more than 3 days; talk with doctor.
    • If you have asthma, talk with doctor.
    • If you have high blood sugar (diabetes), talk with doctor.
    • If you have heart disease, talk with doctor.
    • If you have high blood pressure, talk with doctor.
    • If you have thyroid disease, talk with doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with certain other drugs.
    • Tell doctor if you are pregnant or plan on getting pregnant.
    • Tell doctor if you are breast-feeding.

    Side Effects

    • Nose irritation.


    • Change in health problem being treated. Is it better, worse, or about the same?

    Contact a healthcare provider

    • If you suspect an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Chest pain or pressure, fast heartbeat, or passing out.
    • Very bad headache.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada return any unused drugs back to the pharmacy. Also, visit for more facts about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, supplements, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for health help about side effects. You may also call the FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
    • Talk with doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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