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Antiprotozoals



Depletions

Antiprotozoals/Nutrient Depletion:
  • CalciumCalcium: According to human case reports, hypocalcemia may be associated with pentamidine administration (2316230, 8801377).
  • FolateFolate: According to animal study, pyrimethamine (Daraprim®) is a folate antagonist that may prevent conversion of folic acid to its active form and may reduce serum folate levels (3630970). Pentamidine is a prescription drug used to treat Pneumocystis carinii pneumonia. According to secondary sources, decreased serum folate levels and megaloblastic bone marrow changes may occur rarely with prolonged intravenous pentamidine (Pentacarinat®, Pentam 300®) therapy.
  • MagnesiumMagnesium: According to human case reports, symptomatic hypomagnesemia may occur with pentamidine (NebuPent®, Pentacarinat®, Pentam 300®), particularly if given intravenously (2316230, 8801377, 1866558). This is likely due to renal tubular injury, leading to increased urinary loss of magnesium.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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