Antiobesity Agents/Nutrient Depletion:
- Beta-caroteneBeta-carotene: Based on human evidence, orlistat (Xenical®) may decrease absorption of beta-carotene and other fat-soluble vitamins (8852391). The manufacturer of orlistat recommends that patients take a multivitamin supplement and separate the dosing time by at least two hours from orlistat.
- CalciumCalcium: Based on human evidence, orlistat (Xenical®), a pancreatic lipase inhibitor, has been shown to induce a relative increase in bone turnover (increased resorption or bone loss), which may be due to the malabsorption of vitamin D and/or calcium (11486790).
- Vitamin A/retinolVitamin A/retinol: Based on human evidence, orlistat (Xenical®) may decrease the absorption of fat-soluble vitamins, although studies suggest that vitamin A is not affected as much by orlistat as other fat-soluble vitamins (8844448). Nonetheless, the manufacturer of orlistat recommends that all patients take a multivitamin supplement containing all the fat-soluble vitamins (including vitamins A, D, E, and K unless otherwise contraindicated), separating the dosing time by at least two hours from orlistat.
- Vitamin D/calciferolVitamin D/calciferol: Based on human evidence, orlistat (Xenical®) may reduce vitamin D levels (9225173). The manufacturer of orlistat recommends that patients may consider taking a multivitamin with fat-soluble vitamins at least two hours before or after orlistat, or at bedtime.
- Vitamin EVitamin E: Based on human evidence, orlistat (Xenical®) may reduce dietary vitamin E absorption (8844448).
- Vitamin KVitamin K: Based on human study, orlistat treatment for three to six months may cause a decrease in vitamin K due to reduced absorption in the gastrointestinal (GI) tract (12126214).
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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.