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Polypodium leucotomos extract and anapsos



Interactions

Polypodium leucotomos extract/Drug Interactions:
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Polypodium has been shown to inhibit platelet activating factor activity in vitro (4; 5).
  • AntihypertensivesAntihypertensives: A pharmacodynamic study of a different fern species, Polypodium vulgare, reported hypotension and tachycardia in dogs, possibly due to beta-agonist activity (8). In theory, the hypotensive effects of other drugs may be potentiated.
  • Beta blockersBeta blockers: A pharmacodynamic study of a different fern species, Polypodium vulgare, reported positive inotropic and chronotropic effects in frog hearts, and hypotension and tachycardia in dogs, possibly due to beta-agonist activity (8).
  • Calcium channel blockersCalcium channel blockers: A pharmacodynamic study of a different fern species, Polypodium vulgare, reported positive inotropic and chronotropic effects in frog hearts, and hypotension and tachycardia in dogs, possibly due to beta-agonist activity (8).
  • Cardiac glycosidesCardiac glycosides: A pharmacodynamic study of a different fern species, Polypodium vulgare, reported positive inotropic and chronotropic effects in frog hearts, and hypotension and tachycardia in dogs, possibly due to beta-agonist activity (8).
  • Hydrophilic agentsHydrophilic agents: Theoretically, polypodium may interact with hydrophilic agents (18).
  • ImmunosuppressantsImmunosuppressants: In vitro and animal research of Polypodium leucotomos extract has reported inhibition of cytokine production (interleukin-2, interferon-gamma, tumor necrosis factor-alpha) (9; 10; 11), stimulation of interleukin-1 secretion (7), inhibition of leukotriene B4 formation (12), suppression of T-lymphocyte proliferation, and anti-microbial activity (1).
  • SedativesSedatives: A pharmacodynamic study of a different fern species, Polypodium vulgare, reported CNS depressant effects (8).

Polypodium leucotomos extract/Herb/Supplement Interactions:
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Polypodium has been shown to inhibit platelet activating factor activity in vitro (4; 5).
  • AntioxidantsAntioxidants: In vitro and animal research of Polypodium leucotomos extract (anapsos) has reported free radical scavenging activity (2; 3).
  • Cardiac glycosidesCardiac glycosides: A pharmacodynamic study of a different fern species, Polypodium vulgare, reported positive inotropic and chronotropic effects in frog hearts, and hypotension and tachycardia in dogs, possibly due to beta-agonist activity (8).
  • Hydrophilic herbsHydrophilic herbs: Theoretically, polypodium may interact with hydrophilic herbs or supplements (18).
  • HypotensivesHypotensives: A pharmacodynamic study of a different fern species, Polypodium vulgare, reported hypotension and tachycardia in dogs, possibly due to beta-agonist activity (8).
  • ImmunostimulantsImmunostimulants: In vitro and animal research of Polypodium leucotomos extract has reported inhibition of cytokine production (interleukin-2, interferon-gamma, tumor necrosis factor-alpha) (9; 10; 11), stimulation of interleukin-1 secretion (7), inhibition of leukotriene B4 formation (12), suppression of T-lymphocyte proliferation and anti-microbial activity (1).
  • SedativesSedatives: A pharmacodynamic study of a different fern species, Polypodium vulgare, reported CNS depressant effects (8).

Polypodium leucotomos extract/Food Interactions:
  • Insufficient available evidence.

Polypodium leucotomos extract/Lab Interactions:
  • Insufficient available evidence.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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