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American hellebore (Veratrum viride)



Interactions

American hellebore/Drug Interactions:
  • AntihypertensivesAntihypertensives: Based on human case series reports, American hellebore or its alkaloidal constituents could cause hypotension (12; 7).
  • Beta-agonist drugsBeta-agonist drugs: The isolated constituent of American hellebore O-acetyljervine has been reported to have beta-agonist activity in laboratory studies (31).
  • Beta-blocker drugsBeta-blocker drugs: In laboratory studies, an isolated alkaloid of American hellebore has been found to have beta-adrenergic blocking activity (13; 32).
  • DiureticsDiuretics: Based on human case series reports, the use of American hellebore or its alkaloidal constituents may cause a decrease in glomerular filtration rate (GFR) and effective renal blood flow (7).
  • Heart Rate-Regulating AgentsHeart Rate-Regulating Agents: Based on human case series reports, the use of American hellebore or its alkaloidal constituents could cause bradycardia (12; 7).
  • Nephrotoxic drugsNephrotoxic drugs: Based on human case series reports, the use of American hellebore or its alkaloidal constituents may cause a decrease in glomerular filtration rate (GFR) and effective renal blood flow (7).
  • Renally-excreted drugsRenally-excreted drugs: Based on human case series reports, the use of American hellebore or its alkaloidal constituents may cause a decrease in glomerular filtration rate (GFR) and effective renal blood flow, thereby altering renal function and altering the renal excretion of drugs (7).

American hellebore/Herb/Supplement Interactions:
  • AntiarrhythmicsAntiarrhythmics: Based on human case series reports, the use of American hellebore or its alkaloidal constituents could cause bradycardia (12; 7).
  • AntihypertensivesAntihypertensives: Based on human case series reports, American hellebore or its alkaloidal constituents could cause hypotension (12; 7).
  • DiureticsDiuretics: Based on human case series reports, the use of American hellebore or its alkaloidal constituents may cause a decrease in glomerular filtration rate (GFR) and effective renal blood flow (7).
  • Nephrotoxic herbsNephrotoxic herbs: Based on human case series reports, the use of American hellebore or its alkaloidal constituents may cause a decrease in glomerular filtration rate (GFR) and effective renal blood flow (7).
  • Renally-excreted herbs and supplementsRenally-excreted herbs and supplements: Based on human case series reports, the use of American hellebore or its alkaloidal constituents may cause a decrease in glomerular filtration rate (GFR) and effective renal blood flow, thereby altering renal function and altering the renal excretion of drugs (7).

American hellebore/Food Interactions:
  • Insufficient available evidence.

American hellebore/Lab Interactions:
  • BUNBUN: Based on human case series reports, the use of American hellebore or its alkaloidal constituents may cause a decrease in glomerular filtration rate (GFR) and effective renal blood flow, thereby altering renal function and altering BUN levels (7).
  • CreatinineCreatinine: Based on human case series reports, the use of American hellebore or its alkaloidal constituents may cause a decrease in glomerular filtration rate (GFR) and effective renal blood flow, thereby altering renal function and altering creatinine levels (7).

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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