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Allspice (Pimenta dioica)



Interactions

Allspice/Drug Interactions:
  • AnalgesicsAnalgesics: In rat study, allspice extracts demonstrated analgesic effects (3).
  • AntibioticsAntibiotics: In in vitro study, allspice demonstrated antibacterial effects (4; 5; 6; 7; 8; 9; 10). Conflicting evidence, however, exists (45; 46).
  • AntidiabeticsAntidiabetics: In in vitro study, allspice demonstrated antidiabetic effects (27; 28).
  • AntifungalsAntifungals: In in vitro study, allspice essential oil demonstrated antifungal effects (12; 13; 14).
  • AntihypertensivesAntihypertensives: In rat study, allspice extract produced a dose-dependent decrease in blood pressure (34; 33), although conflicting evidence exists regarding hypotensive effects (3).
  • Antilipemic agentsAntilipemic agents: In rat study, allspice extract demonstrated antihyperlipidemic effects in rats fed a high-fat diet (HFD) (32).
  • Antineoplastic agentsAntineoplastic agents: In in vitro and laboratory study, allspice reduced the growth of cancer cells (25; 17; 22).
  • Antiulcer agentsAntiulcer agents: In animal study, an aqueous suspension of Pimenta dioica demonstrated antiulcer and cytoprotective activity (2).
  • CNS depressantsCNS depressants: In rat study, Pimenta dioica extracts caused central nervous system (CNS) depression (3; 34).
  • Cytochrome P450metabolized agentsCytochrome P450-metabolized agents: Based on laboratory study, allspice enhanced CYP34A promoter activity (24).
  • EstrogensEstrogens: Based on laboratory study, Pimenta dioica extract demonstrated estrogenic effects (31).
  • Hematological agentsHematological agents: In mouse study, Pimenta dioica neutralized the hemorrhagic effect induced by Bothrops asper (Serpentes: Viperidae) venom (23).
  • ImmunosuppressantsImmunosuppressants: In laboratory study, constituents from Pimenta dioica induced proliferation of T-lymphocytes and macrophages (17).

Allspice/Herb/Supplement Interactions:
  • AnalgesicsAnalgesics: In rat study, allspice extracts demonstrated analgesic effects (3).
  • AntibacterialsAntibacterials: In in vitro study, allspice demonstrated antibacterial effects (4; 5; 6; 7; 8; 9; 10). Conflicting evidence, however, exists (45; 46).
  • AntifungalsAntifungals: In in vitro study, allspice essential oil demonstrated antifungal effects (12; 13; 14).
  • AntilipemicsAntilipemics: In rat study, allspice extract demonstrated antihyperlipidemic effects in rats fed a high fat diet (HFD) (32).
  • AntineoplasticsAntineoplastics: In in vitro and laboratory study, allspice reduced the growth of cancer cells (25; 17; 22).
  • AntioxidantsAntioxidants: Based on laboratory study, allspice constituents demonstrated antioxidant effects (11; 47; 18; 48; 17; 19; 49).
  • Antiulcer herbs and supplementsAntiulcer herbs and supplements: In animal study, an aqueous suspension of Pimenta dioica demonstrated antiulcer and cytoprotective activity (2).
  • Cytochrome P450-metabolized herbs and supplementsCytochrome P450-metabolized herbs and supplements: Based on laboratory study, allspice enhanced CYP34A promoter activity (24).
  • HematologicsHematologics: In mouse study, Pimenta dioica neutralized the hemorrhagic effect induced by Bothrops asper (Serpentes: Viperidae) venom (23).
  • HypoglycemicsHypoglycemics: In in vitro study, allspice demonstrated antidiabetic effects (27; 28).
  • HypotensivesHypotensives: In rat study, allspice extract produced a dose-dependent decrease in blood pressure (34; 33), although conflicting evidence for hypotensive effects exists (3).
  • ImmunosuppressantsImmunosuppressants: In laboratory study, constituents from Pimenta dioica induced proliferation of T-lymphocytes and macrophages (17).
  • PhytoestrogensPhytoestrogens: Based on laboratory study, Pimenta dioica extract demonstrated estrogenic effects (31).
  • SedativesSedatives: In rat study, Pimenta dioica extracts caused central nervous system (CNS) depression (3; 34).

Allspice/Food Interactions:
  • Low-sodium foodsLow-sodium foods: In human study, reduced sodium beef broth was more palatable when allspice was used (30). The authors concluded that allspice may be a satisfying substitute for sodium in foods.
  • Rapeseed oilRapeseed oil: In laboratory study, a rapeseed oil sample treated with allspice extract demonstrated the greatest resistance against lipid oxidation (49).

Allspice/Lab Interactions:
  • Blood pressureBlood pressure: In mouse study, allspice extract induced dose-dependent hypotensive effects (34).
  • Blood glucoseBlood glucose: In in vitro study, allspice demonstrated antidiabetic effects (27; 28).
  • Levels of drugs metabolized by CYP450Levels of drugs metabolized by CYP450: Based on laboratory study, allspice enhanced CYP34A promoter activity (24).
  • Lipid profileLipid profile: In rat study, allspice extract demonstrated antihyperlipidemic effects in rats fed a high-fat diet (HFD) (32).
  • WBC (white blood cell) countWBC (white blood cell) count: In laboratory study, constituents from Pimenta dioica induced proliferation of T-lymphocytes and macrophages (17).

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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