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Ackee (Blighia sapida)



Interactions

Ackee/Drug Interactions:
  • Antidiabetic agentsAntidiabetic agents: Ackee may interact with diabetes medication because toxic hypoglycemic syndrome after ingesting ackee has been reported in humans (4; 6). Hypoglycin A also induced a fall in blood glucose in rats (30).
  • Methylene blueMethylene blue: Based on animal evidence, methylene blue may act as an antidote for ackee poisoning if given within one hour of poisoning (17).

Ackee/Herb/Supplement Interactions:
  • HypoglycemicsHypoglycemics: Ackee may interact with hypoglycemic/hyperglycemic herbs because toxic hypoglycemic syndrome after ingesting ackee has been reported in humans (4; 6). Hypoglycin A also induced a fall in blood glucose in rats (30).

Ackee/Food Interactions:
  • Insufficient available evidence.

Ackee/Lab Interactions:
  • GeneralGeneral: Ackee may affect blood glucose, blood electrolytes, renal function, liver function, ammonaemia, coagulation tests, lactate and arterial pH. Ackee may affect medium-chain fatty acid levels in the urine. At autopsy massive liver steatosis is observed (15).
  • Alkaline phosphateAlkaline phosphate: Changes in blood levels may occur with ackee ingestion (21).
  • ALTALT: Changes in blood levels may occur with ackee ingestion (21).
  • Aspartate aminotransferaseAspartate aminotransferase: Decreased levels have been observed in rats (23).
  • ASTAST: Changes in blood levels may occur with ackee ingestion (21).
  • BilirubinBilirubin: Changes in blood levels may occur with ackee ingestion (21). Although there have also been reports of ackee use without resultant changes in bilirubin levels. (23).
  • Cell countsCell counts: Intraperitoneal administration of the lipid portion of the unripe ackee arillus (oil) resulted in marked neutropenia and increased platelets without anemia in rats (23).
  • Dicarboxylic acidDicarboxylic acid: Concentrations of dicarboxylic acid were 4-200 times higher in urine as compared with controls (9).
  • GlucoseGlucose: No changes in glucose were observed in rats (23). Hypoglycin A induced a fall in blood glucose in rats (30). Toxic hypoglycemic syndrome has been reported in humans (4; 6).
  • SodiumSodium: Decreased levels in rats (23).
  • UreaUrea: Decreased levels in rats (23).

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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